PODCAST SERIES: When Methodology Meets Technology: Exploring how intelligent trial design and digital agility reshape clinical trials
Adaptive trial designs offer the flexibility to respond to accumulating data—but implementing them successfully requires careful statistical planning, reliable data and technology capable of supporting complex randomization pathways.
Episode 1: From Protocol to Platform: Flexible Randomization and Seamless Design in Practice
This episode explores how adaptive trial designs move from statistical methodology to real-world implementation. Experts from IDDI and Marvin EDC discuss how group-sequential, seamless, umbrella, basket and platform designs can improve trial efficiency when carefully planned. They also examine the technology required to support flexible randomization, complex treatment pathways and reliable data capture—highlighting why successful adaptive trials depend on aligning robust statistical planning with flexible clinical trial technology.
Speakers:
- Leandro Garcia Barrado, Principal Statistical Scientist, IDDI
- Anita Popp, Customer Success Manager, Marvin EDC by AB Cube
Key Learnings:
- Understand what makes a trial adaptive: See how predefined modifications can use accumulating trial data
- Explore the main adaptive design options: Learn about group-sequential, seamless, umbrella, basket and platform designs
- See how seamless Phase II/III designs work: Discover how combining phases can potentially reduce timelines and patient requirements
- Connect statistical design with technical implementation: Explore how flexible randomization, reliable data and technology support complex adaptive trials
Watch episode 2: Turning Data Into Decisions: Real-Time Reporting Meets Group-Sequential Designs
Watch episode 3: From Data to Delivery: EDC’s Role in Accelerated Approvals and Trustworthy Evidence
Continue the conversation at our upcoming webinar:
Project Optimus Meets EDC: Operationalizing Optimal Dose Trials from Design to Data
Thursday 15 October | 4pm CET / 10am ET
About the podcast series:
When Methodology Meets Technology explores how intelligent trial design and digital agility can work together to address the growing complexity of clinical research. Across three episodes, experts from IDDI and Marvin EDC discuss how statistical innovation, connected data and flexible technology can help translate advanced trial designs into clinical practice.
