STUDY DESIGN

Pragmatic, Innovative, and Compliant Clinical Study Design

Well-designed clinical trials are critical to the development and commercial success of new drugs, biologics, biomarkers, and devices.

At IDDI, we base our clinical study design solutions on statistical expertise and research experience, so your product is ready for fast FDA-EMA review.  

Proven Expertise in Clinical Study Design

For over 3 decades, IDDI has conducted research in statistics and trial design, made significant contributions to scientific literature, and designed over 550 trials across various therapeutic areas, including oncology (immunotherapy and cell and gene therapy), CNS, ophthalmology, and rare diseases. 

Your Complete Solution for Clinical Trial Design

Your clinical trial has unique design and implementation constraints, from budget and time line to study population.

To help meet these demands, our study design services include:

  • Adjusted level of complexity

Conventional, group-sequential, adaptive, and biomarker-based and complex and innovative designs

  • Appropriate statistical framework

Frequentist and Bayesian designs

  • Optimized interim decisions

Stopping rules, group-sequential designs, sample-size reestimation

  • Bias-mitigating methods

Randomization procedures, sound use of real-world data (RWD) and evidence (RWE)

  • PK/PD analysis

Non-compartmental analysis (NCA), population pharmacokinetics (PK), modeling

  • Input on other study features

Population, endpoints, outcome assessments

  • Generalized Pairwise Comparisons – GPC

An innovative statistical method for the design and analysis of clinical trials focusing on multiple dimensions, thus enabling sponsors to incorporate all key patient-relevant outcomes in treatment decision (i.e. in primary analysis)

Benefits:

  • Increased clinical relevance
  • Better leverage your collected data
  • Clinical trial designs with multiple endpoints
  • Reduced sample size
  • Sample-size calculation and simulations

Optimize Your Clinical Development Strategy With Study Design Experts

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