Applied Surrogate Endpoint Evaluation Methods with SAS and R

February 16, 2017

Surrogate Endpoint Evaluation Methods

We wish to draw your attention on the publication of a valuable book Applied Surrogate Endpoint Evaluation Methods with SAS and R co-authored by IDDI and edited by Chapman and Hall/CRC. Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene,
​Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst


An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way.

This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.Surrogate Endpoint Evaluation Methods


  • Offers the reader a non-technical overview of contemporary surrogate endpoint evaluation methods with a focus on the meta-analytic and information-theoretic methods
  • Keeps theory to a minimum and omits statistical details to the extent possible
  • Focuses on providing a general understanding of the different methods, their advantages and disadvantages and their use in practical settings with an emphasis on the interpretation of the results
  • Accompanies the book with a collection of SAS macros and an R library

Biostatistics is IDDI’s core expertise. Should you require further information on our services please do not hesitate to contact us.